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does effexor xr cause weight gain

There have been reports of increases in prothrombin time, partial thromboplastin time, does effexor xr cause weight gain INR when venlafaxine was given to patients receiving warfarin therapy. Top Side Effects by Body System Gastrointestinal Gastrointestinal side effects have frequently included nausea (up to 35%), does effexor xr cause weight gain mouth (14% to 18%), constipation (12%), anorexia (12% to 23%), vomiting, diarrhea (5% to 12%), eructation, abdominal pain, and flatulence. Gastrointestinal side effects reported in premarketing Phase 3 trials have included increased appetite, bruxism, colitis, dysphagia, tongue edema, esophagitis, gastritis, gastroenteritis, gastrointestinal ulcer, gingivitis, glossitis, rectal hemorrhage, hemorrhoids, melena, oral moniliasis, stomatitis, mouth ulceration, abdominal distention, biliary pain, cheilitis, cholecystitis, cholelithiasis, esophageal spasms, duodenitis, hematemesis, gastroesophageal reflux disease, gastrointestinal hemorrhage, gum hemorrhage, hepatitis, ileitis, jaundice, intestinal obstruction, liver tenderness, parotitis, periodontitis, proctitis, rectal disorder, salivary gland enlargement, increased does effexor xr cause weight gain soft stools, and tongue discoloration. Nervous system Nervous does effexor xr cause weight gain side effects have frequently included dizziness (16%), somnolence (up to 14%), insomnia (11% to 25%), fatigue (11%), nervousness (9%), abnormal dreams, sleep abnormalities, tremor, depression, paresthesia, decreased libido, agitation, hypertonia, anxiety, delirium, and twitching. A case of increased libido and spontaneous erections has also been reported. Although rare, several cases of venlafaxine- induced urinary symptoms including nocturia, enuresis, increased urge/frequency, and incontinence have been reported. Consequently, it is not possible to provide a meaningful estimate of the proportion of individuals experiencing adverse events without first grouping similar types of untoward events into a smaller number of standardized event categories. In the tabulations that follow, reported adverse events were classified using a does effexor xr cause weight gain COSTART-based Dictionary terminology. Tachycardia and QTc prolongation appear to occur in a dose-dependent manner. In one case report, venlafaxine (75 mg 3 times/day) may have contributed to an elevation in defibrillation threshold in a patient with nonischemic cardiomyopathy and an implantable cardioverter- defibrillator. Consequently, it is not possible to provide a meaningful estimate of the proportion of individuals experiencing adverse events without first grouping similar types of untoward events into a smaller number of standardized event categories. In the tabulations that follow, reported adverse events were classified using a standard COSTART-based Dictionary terminology. The onset of venlafaxine- associated interstitial pneumonitis has ranged from 1 to 18 months after initial exposure to the drug and symptomatic improvement occurred after discontinuation of venlafaxine and treatment with corticosteroids. Top More Effexor resources Effexor Detailed Consumer Information (PDR) Effexor Prescribing Information (FDA) Effexor Consumer Overview Effexor Advanced Consumer (Micromedex) - Includes Dosage Information Effexor MedFacts Consumer Leaflet (Wolters Kluwer) Venlafaxine Prescribing Information (FDA) Effexor XR Prescribing Information (FDA) Effexor XR Extended-Release Capsules MedFacts Consumer Leaflet (Wolters Kluwer).

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does effexor xr cause weight gain

Experience with the immediate-release venlafaxine showed that sustained hypertension was dose-related, increasing from 3% to 7% at 100 to 300 mg/day to 13% at doses above 300 mg/day. The onset of withdrawal symptoms ranges from 14 to 48 hours after the last dose of venlafaxine extended-release and symptoms tend to resolve rapidly (range, within 2 to 24 hours) after resumption of therapy. Although these events occurred during treatment with venlafaxine, causality has not been determined. Musculoskeletal Musculoskeletal side effects have included rhabdomyolysis. Musculoskeletal side effects reported in premarketing Phase 3 trials have included arthralgia, arthritis, arthrosis, bone spurs, bursitis, leg cramps, myasthenia, tenosynovitis, bone pain, pathological fracture, muscle cramp, muscle spasms, musculoskeletal stiffness, myopathy, osteoporosis, osteosclerosis, plantar fasciitis, rheumatoid arthritis, and tendon rupture. The antidepressants that increase serotonin function appear to have the greatest effect on REM sleep. In one case, toxic hepatitis associated with low dose (37.5 mg/day) venlafaxine was reported in a patient with a history of chronic hepatitis. Endocrine Endocrine side effects have included flushing. Endocrine side effects reported in premarketing Phase 3 trials have rarely included galactorrhea, goiter, hyperthyroidism, hypothyroidism, thyroid nodule, and thyroiditis. During its premarketing assessment, multiple doses of Effexor XR were also administered to 1381 patients in Phase 3 GAD studies and 277 patients in Phase 3 Social Anxiety Disorder studies. However, there is a dose dependency for blood pressure increase. Laboratory Changes Of the serum chemistry and hematology parameters monitored during clinical trials with Effexor, a statistically significant difference with placebo was seen only for serum cholesterol. Clinically does effexor xr cause weight gain increases in serum cholesterol, defined as 1) a final on-therapy increase in serum cholesterol ≥50 mg/dL from baseline and to a value ≥261 mg/dL or 2) an average on‑therapy increase in serum cholesterol ≥50 mg/dL from baseline and to a value ≥261 mg/dL, were recorded in 5.3% of venlafaxine-treated patients and 0.0% of placebo-treated patients. ECG Changes In an analysis of ECGs obtained in 769 patients treated with Effexor and 450 patients treated with placebo in controlled clinical does effexor xr cause weight gain the only does effexor xr cause weight gain significant difference observed was for heart rate, ie, a mean increase from baseline of 4 beats per minute for Effexor. Hyponatremia tends to develop within the first few weeks of treatment (range 3 to does effexor xr cause weight gain days) and typically resolves within 2 weeks (range 48 hours to 6 weeks) after therapy has been discontinued with some patients requiring treatment. Although these events occurred during treatment with venlafaxine, causality has not been determined. Respiratory Respiratory side effects have frequently included pharyngitis, sinusitis, and yawning. Respiratory side effects reported in premarketing Phase 3 trials have included increased cough, dyspnea, asthma, chest congestion, epistaxis, hyperventilation, laryngismus, laryngitis, pneumonia, voice alteration, atelectasis, hemoptysis, hypoventilation, hypoxia, larynx edema, pleurisy, pulmonary embolus, and sleep apnea. Although these events occurred during treatment with venlafaxine, causality has not been determined. There have been postmarketing reports of angioedema. Genitourinary One case of unexpected orgasm and subsequent ejaculation with no erection as well as orgasmic episodes with no ejaculation or erection has also been reported. All reported events are included except those already listed in Table 2 and those events for which does effexor xr cause weight gain drug cause was remote. Although these events occurred does effexor xr cause weight gain treatment with venlafaxine, causality has not been determined. A case of dose-related increase of intraocular pressure caused by venlafaxine use has been reported. Metabolic Metabolic side effects have included weight loss (3%). Metabolic side effects reported in premarketing Phase 3 trials have included weight gain, increased alkaline phosphatase, dehydration, hypercholesteremia, hyperglycemia, hyperlipemia, hypoglycemia, hypokalemia, increased SGOT (AST), increased SGPT (ALT), thirst, bilirubinemia, increased BUN, increased creatinine, diabetes mellitus, glycosuria, gout, abnormal healing, hemochromatosis, hypercalcinuria, hyperkalemia, hyperphosphatemia, hyperuricemia, hypocholesteremia, hyponatremia, hypophosphatemia, hypoproteinemia, and uremia. The rule for including events was to enumerate those that occurred at does effexor xr cause weight gain incidence of 5% or more for at least one of the venlafaxine groups and for which the incidence was at least twice the placebo incidence for at least one Effexor group. Consequently, it is not possible to provide a meaningful estimate of the proportion of individuals experiencing adverse events without first grouping similar types of untoward events into a smaller number of standardized event categories. In the tabulations that follow, reported adverse events were classified using a standard COSTART-based Dictionary terminology. ough increased, and dysmenorrhea3. — Incidence less than 1%. 2 Incidence based on number of male patients. 3 Incidence based on number of female patients. Body as a Whole Headache 25% 24%   Asthenia 12% 6%   Infection 6% 5%   Chills 3% —   Chest does effexor xr cause weight gain blood pressure/hypertension 2% —   Tachycardia 2% —   Postural hypotension 1% —         Dermatological Sweating 12% 3%   Rash 3% 2%   Pruritus 1% —         Gastrointestinal Nausea 37% 11%   Constipation 15% 7%   Anorexia 11% 2%   Diarrhea 8% 7%   Vomiting 6% 2%   Dyspepsia 5% 4%   Flatulence 3% 2%         Metabolic Weight loss 1% —         Nervous System Somnolence 23% 9%   Dry mouth 22% 11%   Dizziness 19% 7%   Insomnia 18% 10%   Nervousness 13% 6%   Anxiety 6% 3%   Tremor 5% 1%   Abnormal dreams 4% 3%   Hypertonia 3% 2%   Paresthesia 3% 2%   Libido decreased 2% —   Agitation 2% —   Confusion 2% 1%   Thinking abnormal 2% 1%   Depersonalization 1% —   Depression 1% —   Urinary retention 1% —   Twitching 1% —         Respiration Yawn 3% —         Special Senses Blurred vision 6% 2%   Taste perversion 2% —   Tinnitus 2% —   Mydriasis 2% —         Urogenital System Abnormal ejaculation/ orgasm 12%2 —2   Impotence 6%2 —2   Urinary frequency 3% 2%   Urination impaired 2% —   Orgasm disturbance 2%3 —3 Dose Dependency of Adverse Events A comparison of adverse event rates in a fixed-dose study comparing Effexor (venlafaxine hydrochloride) 75, 225, and 375 mg/day with placebo revealed a dose dependency for some of the more common adverse events associated with Effexor use, as shown in the table that follows.