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Safety of combined use of PDE5 inhibitors and alpha-blockers may be affected by other variables, including intravascular volume depletion and other anti-hypertensive drugs. The use of Levitra offers no protection against sexually transmitted diseases. This information levitra drug class a summary only.

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Hepatic Insufficiency: In volunteers with mild hepatic impairment (Child-Pugh A), the Cmax and AUC levitra drug class a 10 mg vardenafil dose were increased by 22% and 17%, respectively, compared to healthy control subjects. You should contact the prescribing physician if alpha-blockers or other drugs that lower blood pressure are prescribed by another healthcare provider. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Other nervous system side effects reported in less than 2% of patients have included hypertonia, hypesthesia, insomnia, paresthesia, somnolence, and vertigo. Wayne, NJ 07470 Made in Germany Marketed By GlaxoSmithKline Research Triangle Park NC 27709 Distributed and Marketed By: Schering-Plough levitra drug class Corporation Kenilworth, NJ 07033 Levitra is a registered trademark of Bayer Aktiengesellschaft and is used under license by GlaxoSmithKline and Schering Corporation. Levitra may be taken with or without meals. Levitra is usually taken only when needed, about 60 minutes before sexual activity. In some cases, medical conditions and other factors were reported that may have also played a role in the otologic adverse events. Symptoms of a stroke may include confusion; vision or speech changes; one-sided weakness; or fainting. Patients should be counseled that concomitant use of Levitra with nitrates could cause blood pressure to suddenly drop to an unsafe level, resulting in dizziness, syncope, or even heart attack or stroke. Take each dose with a full glass of water. The absence of levitra drug class warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. How should I take Levitra? Take Levitra exactly as prescribed by your doctor. Consequently, it is recommended not to exceed a single 2.5 mg Levitra dose in a 72-hour period when used in combination with ritonavir (see WARNINGS and DOSAGE AND ADMINISTRATION). Adverse Reactions Levitra was administered to over 4430 men (mean age 56, range 18-89 years; 81% White, 6% Black, 2% Asian, 2% Hispanic and 9% Other) during controlled and uncontrolled clinical trials worldwide. Follow your doctor's instructions. How should I take vardenafil? Take exactly as prescribed by your doctor. Sudden decreases in hearing and loss of hearing have been reported in some patients who have taken Levitra. This has occurred in a small number of people taking vardenafil, most of whom also had heart disease, diabetes, high blood pressure, high cholesterol, or certain pre-existing eye problems, and in those who smoke or are over 50 years old. It is not possible to determine whether these events are related directly to the use of PDE5 inhibitors, to the patient’s underlying vascular risk factors or anatomical defects, to a combination of these factors, or to other factors (see PRECAUTIONS, Information for Patients). To prevent them, sit up or stand slowly, especially in the morning. Metabolism: Vardenafil is metabolized predominantly by the hepatic enzyme CYP3A4, with contribution from the CYP3A5 and CYP2C isoforms. HIV Protease Inhibitors: Indinavir (800 mg t.i.d.) co-administered with Levitra 10 mg resulted in levitra drug class 16-fold increase in vardenafil AUC, a 7-fold increase in vardenafil Cmax and a 2-fold increase in vardenafil half-life. The following cardiovascular side effects have been associated with the use of sildenafil in less than levitra drug class of patients: angina levitra drug class chest pain, hypertension, hypotension, myocardial ischemia, palpitation, postural hypotension, syncope, and tachycardia. The following section identifies additional, less frequent events (<2%) reported during the clinical development of Levitra. Blood pressure and pulse were evaluated over the 6-hour interval after vardenafil dosing. While this normally would be expected to be of little consequence in most patients, prior to prescribing Levitra, physicians should carefully consider whether their patients with underlying cardiovascular disease could be affected adversely by such vasodilatory effects. Before using Levitra: Some medical conditions may interact with Levitra. Geriatrics: A starting dose of 5 mg Levitra should be considered in patients ≥65 years of age (see CLINICAL PHARMACOLOGY, Pharmacokinetics in Special Populations and PRECAUTIONS). This dose is approximately 100 fold (rat) and 29 fold (rabbit) greater than the AUC values for unbound vardenafil and levitra drug class major metabolite in humans given the MRHD of 20 mg.