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If OVERDOSE is suspected: Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency generic substitute for lipitor immediately. Table 2. Following discontinuation of atorvastatin, the patient experienced significant clinical improvement with only mild residual aponeurotic ptosis after 2 months. Treating to New Targets Study (TNT) In TNT . Increases in liver function tests (LFT) in other patients were not associated with jaundice or other clinical signs or symptoms. If any develop or change in intensity, inform your doctor as soon as possible.

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Studies in rats performed at doses up to 175 mg/kg (15 times the human exposure) produced no changes in fertility. Patients were mainly male (81%), white (99%) with an average age of 61.7 years, and an average LDL-C of 121.5 mg/dL at randomization; 76% were on statin therapy. Other variables associated with an increased risk of statin-induced myopathy include, advanced age, small body stature, female gender, renal and/or hepatic dysfunction, perioperative periods, hypothyroidism, diabetes mellitus, and alcoholism. Do not give Lipitor to other people, even if they have the same problem you have. Respiratory Respiratory symptoms reported since market introduction have included bronchitis, rhinitis, pharyngitis, and sinusitis. Lipitor reduces LDL-C in some patients with homozygous familial hypercholesterolemia (FH), a population that rarely responds to other lipid-lowering medication(s). Liver enzyme changes generally occur in the first 3 months of treatment with Lipitor. The effect of Lipitor was seen regardless of baseline LDL levels. Combined Patients With Isolated Elevated TG: Median (min, max) Percentage Change From Baseline Placebo (n=12) Lipitor 10 mg (N=37) Lipitor 20 mg (N=13) Lipitor 80 mg (N=14) Triglycerides -12.4 (-36.6, 82.7) -41.0 (-76.2, generic substitute for lipitor -38.7 (-62.7, 29.5) -51.8 (-82.8, 41.3) Total-C -2.3 (15.5, 24.4) -28.2 (-44.9, -6.8) -34.9 (-49.6, -15.2) -44.4 (-63.5, -3.8) LDL-C 3.6 (-31.3, 31.6) -26.5 (-57.7, 9.8) -30.4 (-53.9, 0.3) -40.5 (-60.6, -13.8) HDL-C 3.8 (-18.6, 13.4) 13.8 generic substitute for lipitor 61.5) 11.0 (-3.2, 25.2) 7.5 (-10.8, 37.2) VLDL-C -1.0 (-31.9, 53.2) -48.8 (-85.8, 57.3) -44.6 (-62.2, -10.8) generic substitute for lipitor (-88.2, 37.6) non-HDL-C -2.8, (-17.6, 30.0) -33.0 (-52.1, -13.3) -42.7 (-53.7, -17.4) -51.5 (-72.9, -4.3) 14.4 Dysbetalipoproteinemia (Fredrickson Type III) The results of an open-label crossover study of 16 patients (genotypes: 14 apo E2/E2 and 2 apo E3/E2) with dysbetalipoproteinemia (Fredrickson Type III) are shown in the table below ( Table 9). Clinical studies have shown that Lipitor does not reduce basal plasma cortisol concentration or impair adrenal reserve. An effect of Lipitor was seen regardless of age, sex, or baseline lipid levels. ADULTS The recommended starting dose is 10 or 20 milligrams once a day. Additionally, all patients had at least 3 of the following cardiovascular risk factors: male gender (81.1%), age greater than 55 years (84.5%), smoking (33.2%), diabetes (24.3%), history of CHD in a first-degree relative (26%), TC:HDL greater than 6 (14.3%), generic substitute for lipitor vascular disease (5.1%), left ventricular hypertrophy (14.4%), prior cerebrovascular event (9.8%), specific ECG abnormality (14.3%), proteinuria/albuminuria (62.4%). Certain other drugs can increase your risk of serious muscle generic substitute for lipitor and it is very important that your doctor knows if you are using any of them: diltiazem (Cartia, Cardizem); gemfibrozil (Lopid), fenofibric acid (Fibricor, Trilipix), or fenofibrate (Antara, Fenoglide, Lipofen, Lofibra, Tricor, Triglide); antibiotics such as clarithromycin (Biaxin) or erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin); antifungal medications such as fluconazole (Diflucan), itraconazole (Sporanox), or ketoconazole (Extina, Ketozole, Nizoral, Xolegal); HIV medications such as atazanavir (Reyataz), ritonavir (Norvir), lopinavir/ritonavir (Kaletra), saquinavir (Invirase), and others; medicines that contain niacin (Advicor, Niaspan, Niacor, Simcor, Slo-Niacin, and others); or drugs that weaken your immune system, such as steroids, cancer medicine, or medicines used to prevent organ transplant rejection, such as cyclosporine (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune), or tacrolimus (Prograf). Male rats given 100 mg/kg/day for 11 weeks prior to mating had decreased sperm motility, spermatid head concentration, and increased abnormal sperm. Lipitor may also be used for other purposes not listed in this medication guide. These have been reported in less than 4% of patients and have included constipation, flatulence, dyspepsia, and abdominal pain. In the Lipitor placebo-controlled clinical trial database of 16,066 patients (8755 Lipitor vs. Possible side effects of Lipitor: All medicines may cause generic substitute for lipitor effects, but many people have no, or minor, side effects. The overall risk reduction was consistent regardless of age (less than 65, greater than generic substitute for lipitor equal to 65) or gender. A case of dermatomyositis has also been reported. She once again discontinued atorvastatin, and her hematuria rapidly resolved. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. 33, 1.4% placebo; HR: 1.68, 95% CI: 1.09, 2.59; p=0.0168).