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†   See Sections 5.1 and 7 for clinical significance. In animal is lipitor dangerous Lipitor lowers plasma cholesterol and lipoprotein levels by inhibiting HMG-CoA reductase and cholesterol synthesis in the liver and by increasing the number of hepatic LDL receptors on the cell surface to enhance uptake and catabolism of LDL; Lipitor also reduces LDL production and the number of LDL particles. After randomization, patients were treated for 16 weeks with either Lipitor 10 mg per day or a fixed dose of the comparative agent (Table 7). Statins may cause fetal harm when is lipitor dangerous to a pregnant woman.

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is lipitor dangerous

(Pooled results are provided in Table 6.) TABLE 6. Lipid-altering Effects of Lipitor in Adolescent Boys is lipitor dangerous Girls with Heterozygous Familial Hypercholesterolemia or Severe Hypercholesterolemia (Mean Percentage Change From Baseline at Endpoint in Intention-to-Treat Population) DOSAGE N Total-C LDL-C HDL-C TG Apolipoprotein B Placebo 47 -1.5 -0.4 -1.9 1.0 0.7 Lipitor 140 -31.4 -39.6 2.8 -12.0 -34.0 The mean achieved LDL-C value was 130.7 mg/dL (range: 70.0–242.0 mg/dL) in the Lipitor group compared to 228.5 mg/dL (range: 152.0–385.0 mg/dL) in the placebo group during the 26-week double-blind phase. How Should I Take Lipitor? Take Lipitor exactly as prescribed by your doctor. Atorvastatin may also increase the incidence of hemorrhagic stroke in patients with a history of recent stroke or TIA. Multum's is lipitor dangerous information is lipitor dangerous an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the is lipitor dangerous skill, knowledge and judgment of healthcare practitioners. Due to extensive drug binding to plasma proteins, hemodialysis is not expected to significantly enhance Lipitor clearance. Lipitor is only part of a complete program of treatment that also includes diet, is lipitor dangerous and weight control. is lipitor dangerous were no significant differences between the treatment groups for all-cause mortality: 216 (9.1%) in the Lipitor 80 mg/day group vs. The dosage may be increased after 4 weeks, as determined by the doctor, up to a maximum of 20 milligrams a day. If you miss a dose of Lipitor, take it as soon as you remember. Rx Only Manufactured by Pfizer Ireland Pharmaceuticals Dublin, Ireland LAB-0348-4.0 June 2009 PRINCIPAL DISPLAY PANEL LipitorŽ                  10 (atorvastatin calcium) tablets 10 mg LipitorŽ                  20 (atorvastatin calcium) tablets 20 mg LipitorŽ                  40 (atorvastatin calcium) tablets 40 mg LipitorŽ                  80 (atorvastatin calcium) tablets 80 mg Lipitor  atorvastatin calcium  tablet, film coated Product Information Product Type HUMAN PRESCRIPTION DRUG NDC Product Code (Source) 54868-4229 (0071-0157) Route of Administration ORAL DEA Schedule      Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength ATORVASTATIN CALCIUM (ATORVASTATIN) ATORVASTATIN CALCIUM 40 mg Inactive Ingredients Ingredient Name Strength CALCIUM CARBONATE   CANDELILLA WAX   CROSCARMELLOSE SODIUM   HYDROXYPROPYL CELLULOSE   LACTOSE MONOHYDRATE   MAGNESIUM STEARATE   CELLULOSE, MICROCRYSTALLINE   HYPROMELLOSE   POLYETHYLENE GLYCOL   TALC   TITANIUM DIOXIDE   POLYSORBATE 80   Product Characteristics Color white is lipitor dangerous no score Shape OVAL (elliptical) Size 15mm Flavor Imprint Code PD;157;40 Contains      Packaging # NDC Package Description Multilevel Packaging 1 54868-4229-0 30 TABLET In 1 BOTTLE None 2 54868-4229-1 90 TABLET In 1 BOTTLE None 3 54868-4229-2 is lipitor dangerous In 1 BOTTLE None 4 54868-4229-3 45 TABLET In 1 BOTTLE None Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date NDA NDA020702 07/06/2000 Lipitor  atorvastatin calcium  tablet, film coated Product Information Product Type HUMAN PRESCRIPTION DRUG NDC Product Code (Source) 54868-3946 (0071-0156) Route of Administration ORAL DEA is lipitor dangerous      Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength is lipitor dangerous CALCIUM (ATORVASTATIN) ATORVASTATIN is lipitor dangerous 20 mg Inactive Ingredients Ingredient Name Strength CALCIUM CARBONATE   CANDELILLA WAX   CROSCARMELLOSE SODIUM   HYDROXYPROPYL CELLULOSE   LACTOSE MONOHYDRATE   MAGNESIUM STEARATE   CELLULOSE, MICROCRYSTALLINE   HYPROMELLOSE   is lipitor dangerous GLYCOL   TALC   TITANIUM DIOXIDE   POLYSORBATE 80   Product Characteristics Color white Score no score Shape OVAL (elliptical) Size 12mm Flavor Imprint Code PD;156;20 Contains      Packaging # NDC Package Description Multilevel Packaging 1 54868-3946-0 30 TABLET is lipitor dangerous BOTTLE None 2 54868-3946-1 15 TABLET In 1 BOTTLE None 3 54868-3946-2 90 TABLET In 1 BOTTLE None 4 54868-3946-3 60 TABLET In 1 BOTTLE None 5 54868-3946-4 45 TABLET In 1 BOTTLE None Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date NDA NDA020702 03/12/2004 Lipitor  atorvastatin calcium  tablet, film coated Product Information Product Type HUMAN PRESCRIPTION DRUG NDC Product Code (Source) 54868-4934 (0071-0158) Route of Administration ORAL DEA Schedule      Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength ATORVASTATIN CALCIUM (ATORVASTATIN) ATORVASTATIN CALCIUM 80 mg Inactive Ingredients Ingredient Name Strength CALCIUM CARBONATE   CANDELILLA WAX   CROSCARMELLOSE SODIUM   HYDROXYPROPYL CELLULOSE   is lipitor dangerous MONOHYDRATE   MAGNESIUM STEARATE   CELLULOSE, MICROCRYSTALLINE   HYPROMELLOSE   POLYETHYLENE GLYCOL   TALC   TITANIUM DIOXIDE   POLYSORBATE 80   Product Characteristics Color white Score no score Shape OVAL (elliptical) Size 19mm Flavor Imprint Code PD;158;80 Contains      Packaging # NDC Package Description Multilevel Packaging 1 54868-4934-0 30 TABLET In 1 BOTTLE None is lipitor dangerous 54868-4934-1 90 TABLET In 1 BOTTLE None Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date NDA NDA020702 01/11/2006 Lipitor  atorvastatin calcium  tablet, film coated Product Information Product Type HUMAN PRESCRIPTION DRUG NDC Product Code (Source) is lipitor dangerous (0071-0155) Route of Administration ORAL DEA Schedule      Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength ATORVASTATIN is lipitor dangerous (ATORVASTATIN) ATORVASTATIN CALCIUM 10 mg Inactive Ingredients Ingredient Name Strength CALCIUM CARBONATE   CANDELILLA WAX   CROSCARMELLOSE SODIUM   HYDROXYPROPYL CELLULOSE   LACTOSE MONOHYDRATE   MAGNESIUM STEARATE   CELLULOSE, MICROCRYSTALLINE   HYPROMELLOSE   POLYETHYLENE GLYCOL   TALC   TITANIUM DIOXIDE   is lipitor dangerous 80   Product Characteristics Color white Score no score Shape OVAL (elliptical) Size 10mm is lipitor dangerous Imprint Code PD;155;10 Contains      Packaging # NDC Package Description Multilevel Packaging 1 54868-3934-3 10 TABLET In 1 BOTTLE None 2 54868-3934-0 30 TABLET In 1 BOTTLE None 3 54868-3934-4 45 TABLET In 1 BOTTLE None 4 54868-3934-2 60 TABLET is lipitor dangerous BOTTLE None 5 54868-3934-1 90 TABLET In 1 BOTTLE None Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date NDA is lipitor dangerous 05/05/1997 Labeler - Physicians Total Care, Inc (194123980) Revised: 08/2009Physicians Total Care, Inc Lipitor Generic Name: Atorvastatin (a-TOR-va-STAT-in) Brand Name: Lipitor Lipitor is used for: Lowering high is lipitor dangerous and triglycerides in certain patients. Multum information has been compiled for use by healthcare practitioners and consumers is lipitor dangerous the United States and therefore Multum does not warrant that is lipitor dangerous outside of the United States are appropriate, unless specifically indicated otherwise. Stop taking Lipitor and call your doctor at once if you have any of these serious side effects: unexplained muscle pain, tenderness, or weakness; fever, unusual tiredness, and dark colored urine; swelling, weight gain, urinating less than usual or not at all; or nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes). It can raise triglyceride levels and may increase your risk of liver damage. The five most common adverse reactions in patients treated with Lipitor that led is lipitor dangerous treatment discontinuation and occurred at a rate greater than placebo were: myalgia (0.7%), diarrhea (0.5%), nausea (0.4%), alanine aminotransferase increase (0.4%), and hepatic enzyme increase (0.4%). Musculoskeletal side effects have included uncomplicated myalgia and arthralgia. Therefore, in patients taking itraconazole, caution should be used when the Lipitor dose exceeds 20 mg .7.2 Grapefruit Juice Contains one or more components that inhibit CYP 3A4 and can increase plasma concentrations of atorvastatin, especially with excessive grapefruit juice consumption (>1.2 liters per is lipitor dangerous Caution should be exercised if a statin is administered concomitantly with drugs that may decrease the is lipitor dangerous or activity of endogenous steroid hormones, such as ketoconazole, spironolactone, and cimetidine. If you do conceive while taking Lipitor, notify your doctor right away. In patients with CHD or multiple risk factors for CHD, Lipitor can be started simultaneously with diet. However, this study was only able to exclude a three-to-four-fold increased risk of congenital anomalies over background incidence. 14.6 Heterozygous Familial Hypercholesterolemia in Pediatric Patients In a double-blind, placebo-controlled study followed by an open-label phase, 187 boys and postmenarchal girls 10–17 years of age (mean age 14.1 years) with heterozygous familial hypercholesterolemia (FH) or severe hypercholesterolemia, were randomized to Lipitor (n=140) or placebo (n=47) for 26 weeks and then all received Lipitor for 26 weeks. It does not contain all information about Lipitor. To get the full benefit of the medication, you need to stick to the diet and exercise program prescribed by your doctor. 211 (8.9%) in the placebo group. The number of Lipitor-treated patients who required uptitration to 20 mg after Week 4 during the double-blind phase was 80 (57.1%). Follow the directions on your prescription label. Do not take 2 doses of Lipitor at the same time.