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Seek medical attention right away if any of these SEVERE side effects occur when using Lipitor: Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bone, joint, or lipitor and crestor together pain; change in the amount of urine produced; chest pain; dark urine; fever, chills, or persistent sore throat; flu-like symptoms; joint pain; muscle pain, lipitor and crestor together or weakness (with or without fever or fatigue); painful or frequent urination; pale stools; red, swollen, blistered, or peeling skin; severe stomach pain; swelling of the hands, ankles, or feet; yellowing of the eyes or skin. Certain other drugs can increase your risk of serious muscle problems, and it is very important that your doctor knows if you are using any of them: diltiazem (Cartia, Cardizem); gemfibrozil (Lopid), fenofibric acid (Fibricor, Trilipix), or fenofibrate (Antara, Fenoglide, Lipofen, Lofibra, Tricor, Triglide); antibiotics such as clarithromycin (Biaxin) or erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin); antifungal medications such as fluconazole (Diflucan), itraconazole (Sporanox), or ketoconazole (Extina, Ketozole, Nizoral, Xolegal); HIV medications such as atazanavir (Reyataz), ritonavir (Norvir), lopinavir/ritonavir (Kaletra), saquinavir (Invirase), and others; medicines that contain niacin (Advicor, Niaspan, Niacor, Simcor, Slo-Niacin, and others); or drugs that weaken your immune system, such as steroids, cancer medicine, or medicines used to prevent organ transplant rejection, such as cyclosporine (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune), or tacrolimus (Prograf). FDA pregnancy category X. Only your doctor can determine if it is safe for you to continue taking Lipitor. There lipitor and crestor together aplasia and aspermia in the epididymis of 2 of 10 rats treated with 100 mg/kg/day of atorvastatin for 3 months (16 times the human AUC at the 80 mg dose); testis weights were significantly lower at 30 and 100 mg/kg and epididymal weight was lower at 100 mg/kg. In this double-blind, placebo-controlled study, patients were treated with anti-hypertensive therapy (Goal BP less than 140/90 mm Hg for non-diabetic patients; less than 130/80 mm Hg for diabetic patients) and allocated to either Lipitor 10 mg daily lipitor and crestor together or placebo (n=5137), using a covariate adaptive method which took into account the distribution of nine baseline characteristics of patients already enrolled and minimized the imbalance of those characteristics across the groups.

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lipitor and crestor together

7.5 Digoxin When multiple doses of Lipitor and digoxin were coadministered, steady state plasma digoxin concentrations increased by approximately 20%. The effect of Lipitor 10 mg/day on lipid levels was similar to that seen in previous clinical trials. Lipitor Side Effects Please note - some side effects for Lipitor may not be reported. Certain other drugs can increase your risk of serious muscle problems, and it is very important that your doctor knows if you are using any of them: diltiazem (Cartia, Cardizem); gemfibrozil (Lopid), fenofibric acid (Fibricor, Trilipix), or lipitor and crestor together (Antara, Fenoglide, Lipofen, Lofibra, Tricor, Triglide); antibiotics such as clarithromycin (Biaxin) or erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin); antifungal medications such as fluconazole (Diflucan), itraconazole (Sporanox), or ketoconazole (Extina, Ketozole, Nizoral, Xolegal); HIV medications such as atazanavir (Reyataz), ritonavir (Norvir), lopinavir/ritonavir (Kaletra), saquinavir (Invirase), and others; medicines that contain niacin (Advicor, Niaspan, Niacor, Simcor, Slo-Niacin, and others); or drugs that weaken your immune system, such as steroids, cancer medicine, or medicines used to prevent organ transplant rejection, such as cyclosporine (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune), or tacrolimus (Prograf). For those at low risk, a medication is considered at readings of 190 or more. Stop taking this medication and tell your doctor right away if you become pregnant. Before taking atorvastatin, tell your doctor if you have ever had liver or kidney disease, diabetes, or a thyroid disorder, or if you drink more than 2 alcoholic beverages daily. In rare cases, atorvastatin can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. If you lipitor and crestor together a dose... passing brown or dark-colored urine. It's important to avoid taking the two drugs at the same time of day. This includes prescription, over-the-counter, vitamin, and herbal products. Overview of Efficacy Results in TNT Endpoint Atorvastatin 10 mg   (N=5006) Atorvastatin  80 mg   (N=4995) HR* (95%CI) PRIMARY ENDPOINT n lipitor and crestor together n (%) lipitor and crestor together major cardiovascular endpoint 548 (10.9) 434 lipitor and crestor together 0.78 (0.69, 0.89) Components of the Primary Endpoint   CHD death 127 (2.5) 101 (2.0) 0.80 (0.61, 1.03)   Non-fatal, non-procedure related MI 308 (6.2) 243 (4.9) 0.78 (0.66, 0.93)   Resuscitated cardiac arrest 26 (0.5) 25 (0.5) 0.96 (0.56, 1.67)   Stroke (fatal and non-fatal) 155 (3.1) 117 (2.3) 0.75 (0.59, 0.96) SECONDARY ENDPOINTS† First CHF with hospitalization 164 (3.3) 122 (2.4) 0.74 (0.59, 0.94) First PVD endpoint 282 (5.6) 275 (5.5) 0.97 (0.83, 1.15) First CABG or other coronary revascularization procedure‡ 904 (18.1) 667 (13.4) 0.72 (0.65, 0.80) First documented angina endpoint‡ 615 (12.3) 545 (10.9) 0.88 (0.79, 0.99) All-cause mortality 282 (5.6) 284 (5.7) 1.01 (0.85, 1.19) Components of All-Cause Mortality   Cardiovascular death 155 (3.1) 126 (2.5) 0.81 (0.64, 1.03)   Noncardiovascular death 127 (2.5) 158 (3.2) 1.25 (0.99, 1.57)     Cancer death 75 (1.5) 85 (1.7) 1.13 (0.83, 1.55)     Other non-CV death 43 (0.9) 58 (1.2) 1.35 (0.91, 2.00)     Suicide, homicide, and other traumatic non-CV death 9 (0.2) 15 (0.3) 1.67 (0.73, 3.82) HR=hazard ratio; CHD=coronary heart disease; CI=confidence interval; MI=myocardial infarction; CHF=congestive lipitor and crestor together failure; CV=cardiovascular; PVD=peripheral vascular disease; CABG=coronary artery bypass graft Confidence intervals for the Secondary Endpoints were not adjusted for multiple comparisons *  Atorvastatin 80 mg; atorvastatin 10 mg †   Secondary endpoints not included in primary endpoint ‡   Component of other secondary endpoints Of the events that comprised the primary efficacy endpoint, treatment with Lipitor 80 mg/day significantly reduced the rate of non-fatal, non-procedure related MI and fatal and non-fatal stroke, but not CHD death or resuscitated cardiac arrest (Table 5). This includes prescription, over-the-counter, vitamin, and herbal products. Subjects were randomly assigned to either 10 mg/day or 80 mg/day of Lipitor and followed for a median duration of 4.9 years. Rx Only Manufactured by: Pfizer Ireland Pharmaceuticals Dublin, Ireland LAB-0021-24.0 June 2009 PATIENT INFORMATION LipitorŽ atorvastatin calcium tablets (LIP-ih-tore) Read the Patient Information that comes with Lipitor before you start taking it and each time you get a refill. Your doctor may occasionally change your dose to make sure you get the best results. You can ask your doctor or pharmacist for information about Lipitor that is written for health professionals. These are not all the side effects of Lipitor. Additionally, analysis of the pooled data demonstrated consistent and significant decreases in total-C, LDL-C, TG, total-C/HDL-C, and LDL-C/HDL-C. lipitor and crestor together can raise triglyceride levels and may increase your risk of liver damage. Diarrhea has been reported in up to 5.3% of patients and may be dose-related. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine. If you get pregnant, stop taking Lipitor right away and call your doctor. If you would like more information, talk with your doctor. Tell your doctor or dentist that you take Lipitor before you receive any medical or dental care, lipitor and crestor together care, or surgery. Figure 3: Effect of Lipitor 80 mg/day vs. How Supplied/Storage and Handling 10 mg tablets: coded "PD 155" on one side and "10" on the other. You can take it in the morning or the evening, but should hold to the same time each day. Do not take in larger or smaller amounts or for longer than recommended. The starting dose and maintenance doses of Lipitor should be lipitor and crestor together according to patient characteristics such as goal of therapy and response (see current NCEP Guidelines). 17.3 Pregnancy Women of childbearing age should be advised to use lipitor and crestor together effective method of birth control to prevent pregnancy while using Lipitor.