lipitor physician's insert
Check with your doctor if any of these most COMMON side effects persist or become bothersome: Constipation; gas; headache; stomach pain or upset; weakness. Lipitor can cause liver problems. Combined Patients With Isolated Elevated TG: Median lipitor physician's insert max) Percentage Change lipitor physician's insert Baseline Placebo (n=12) Lipitor 10 mg (N=37) Lipitor 20 mg (N=13) Lipitor 80 mg (N=14) Triglycerides -12.4 (-36.6, 82.7) -41.0 (-76.2, 49.4) -38.7 (-62.7, 29.5) -51.8 (-82.8, 41.3) Total-C -2.3 (15.5, 24.4) -28.2 (-44.9, -6.8) -34.9 (-49.6, -15.2) -44.4 (-63.5, -3.8) LDL-C 3.6 (-31.3, 31.6) -26.5 (-57.7, 9.8) -30.4 (-53.9, 0.3) -40.5 (-60.6, -13.8) HDL-C 3.8 (-18.6, 13.4) 13.8 (-9.7, 61.5) 11.0 (-3.2, 25.2) 7.5 (-10.8, 37.2) VLDL-C -1.0 (-31.9, 53.2) -48.8 (-85.8, 57.3) -44.6 (-62.2, -10.8) -62.0 (-88.2, 37.6) non-HDL-C -2.8, (-17.6, 30.0) -33.0 (-52.1, -13.3) -42.7 (-53.7, -17.4) -51.5 (-72.9, -4.3) 14.4 Dysbetalipoproteinemia (Fredrickson Type III) The results of an open-label crossover study of 16 patients (genotypes: 14 apo E2/E2 and 2 apo E3/E2) with dysbetalipoproteinemia (Fredrickson Type III) are shown in the table below ( Table lipitor physician's insert In clinical studies, patients reported the following common lipitor physician's insert effects while taking Lipitor: diarrhea, upset stomach, muscle and joint pain, and alterations in some laboratory blood tests. Lipitor does make its way into breast milk, so you should not take the drug while breastfeeding your baby. She presented with gross hematuria of approximately 4 weeks duration. Hepatic In clinical trials, liver enzyme elevations returned to pretreatment levels upon discontinuation or dose reduction of atorvastatin. In rat and rabbit animal reproduction studies, atorvastatin revealed no evidence of teratogenicity. 33/2366, 1.4%) compared to placebo. A history of renal impairment may be a lipitor physician's insert factor for the development of rhabdomyolysis. This is not a complete list of all side effects that may occur. Some baseline characteristics, including hemorrhagic and lacunar stroke on study entry, were associated with a higher incidence of hemorrhagic stroke in the atorvastatin group . If you have questions about side effects, contact your health care provider. 127 events in the placebo group) with a relative risk reduction of 37%, HR 0.63, 95% CI (0.48, 0.83) (p=0.001) (see Figure 2). If the tests reveal a problem, you may have to stop using the drug. Drug information contained herein may be time sensitive. Women who may become pregnant should use effective birth control while taking Lipitor. These doses were 6 to 11 times (mouse) and 8 to 16 times (rat) the human AUC (0–24) based on the maximum recommended human dose of 80 mg/day. The safety and efficacy of doses above 20 mg have not been studied in controlled trials in children. A chemically similar drug in this class produced optic nerve degeneration (Wallerian degeneration of retinogeniculate fibers) in clinically normal dogs in a dose-dependent fashion at a dose that produced plasma drug levels about 30 times higher than the mean drug level in humans taking the highest recommended dose. Discuss the use of grapefruit products with your doctor. Stop taking this medication and tell your doctor right away if you become pregnant. Endocrine Endocrine side effects associated with the use of other HMG-CoA reductase inhibitors have included hypospermia, gynecomastia, and thyroid dysfunction. 17.4 Breastfeeding Women who are breastfeeding should lipitor physician's insert advised to not use Lipitor.
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