lipitor versus simvastatin
Nonclinical Toxicology 13.1 Carcinogenesis, Mutagenesis, Impairment of Fertility In a 2-year carcinogenicity study in rats at dose levels of 10, 30, and 100 mg/kg/day, 2 rare tumors were found in muscle in high-dose females: in one, there was a rhabdomyosarcoma and, in another, there was a fibrosarcoma. Clinical and pathologic studies show that elevated plasma levels of total cholesterol (total-C), LDL-cholesterol (LDL-C), and apolipoprotein B (apo B) promote human atherosclerosis and are risk factors lipitor versus simvastatin developing cardiovascular disease, while increased levels of HDL-C are associated with a decreased cardiovascular risk. In addition, acid maltase deficiency (the genetic disorder also referred to as Pompe's Disease) has been revealed following HMG-CoA therapy in at least one presymptomatic patient. It can raise triglyceride levels and may increase your risk of liver damage. Certain other drugs can increase your risk lipitor versus simvastatin serious muscle problems, and it is very important that your doctor knows if you are lipitor versus simvastatin any of them:
diltiazem (Cartia, Cardizem);
gemfibrozil (Lopid), fenofibric acid (Fibricor, Trilipix), or fenofibrate (Antara, Fenoglide, Lipofen, Lofibra, Tricor, Triglide);
antibiotics such as clarithromycin (Biaxin) or erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin);
antifungal medications lipitor versus simvastatin as fluconazole (Diflucan), itraconazole (Sporanox), or ketoconazole (Extina, Ketozole, Nizoral, lipitor versus simvastatin medications lipitor versus simvastatin as atazanavir (Reyataz), ritonavir (Norvir), lopinavir/ritonavir (Kaletra), saquinavir (Invirase), and others;
medicines that contain niacin (Advicor, Niaspan, Niacor, Simcor, Slo-Niacin, and others); or
drugs that weaken your immune system, such as steroids, cancer medicine, or medicines used to prevent organ transplant rejection, such as cyclosporine (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune), or tacrolimus (Prograf).
FDA pregnancy category X. Take Lipitor each day at any time of day at about the same time each day. Tell your doctor about all other medications you use. Keep a list of all your medicines and show it to any healthcare provider who treats you. Discuss future pregnancy plans with your patients, and discuss when to stop Lipitor if they are trying to conceive. Lipitor is used in adults and children who lipitor versus simvastatin at least 10 years old. See also: Pregnancy and breastfeeding warnings in more lipitor versus simvastatin How should I take Lipitor? Take Lipitor exactly as prescribed by your doctor. Subjects who entered the study with a hemorrhagic stroke appeared to be at increased risk for hemorrhagic stroke [7 (16%) Lipitor vs. Hepatic In clinical trials, liver enzyme elevations returned to pretreatment levels upon discontinuation or dose reduction lipitor versus simvastatin atorvastatin. How should you take Lipitor? Lipitor should be taken once a day, with or without food. The dosage range of Lipitor is 10 to 80 mg once daily. Postmarketing Experience The following adverse reactions have been identified during postapproval lipitor versus simvastatin of Lipitor. NDC 54868-3946-1 bottles of 15 NDC 54868-3946-0 bottles of 30 NDC 54868-3946-4 lipitor versus simvastatin of 45 NDC 54868-3946-3 bottles of 60 NDC 54868-3946-2 bottles of 90 40 mg tablets: coded "PD 157" on one side and "40" on the other. Visit your doctor regularly.
Atorvastatin is only part of a complete program of treatment that also includes diet, exercise, and weight control. Metabolism: Lipitor is extensively metabolized to ortho- and parahydroxylated derivatives and various beta-oxidation products. Your doctor may prescribe it along with a special diet if your blood cholesterol or triglyceride level is high and you have been unable to lower your readings by diet alone.
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