switching from lipitor to simvastatin
8.3 Nursing Mothers It is not known whether atorvastatin is excreted in human milk, but a small amount of another drug in this class does pass into breast milk. Lab tests, including blood cholesterol levels and liver function tests, may be performed while you use Lipitor. 7311 placebo; age range 10–93 years, 39% women, 91% Caucasians, 3% Blacks, 2% Asians, 4% other) with a median treatment duration of 53 weeks, 9.7% of patients on Lipitor and 9.5% of the patients on placebo discontinued due to adverse reactions regardless of causality. Atorvastatin AUC was significantly increased with concomitant administration of Lipitor 10 mg and cyclosporine 5.2 mg/kg/day compared to that of Lipitor alone . In rare cases, Lipitor can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Distribution: Mean volume of distribution of Lipitor is approximately 381 switching from lipitor to simvastatin 548 events in the 10 mg/day switching from lipitor to simvastatin with a relative risk reduction of 22%, HR 0.78, 95% CI (0.69, 0.89), p=0.0002 (see Figure 3 switching from lipitor to simvastatin Table 5). 8.4 Pediatric Use Safety and effectiveness in patients 10–17 years of age with switching from lipitor to simvastatin familial hypercholesterolemia have been evaluated in a controlled clinical trial of 6 months' duration in adolescent boys and postmenarchal girls.
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