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However, this study was only able to exclude a three-to-four-fold increased risk of congenital anomalies over background incidence. Atorvastatin calcium is very slightly soluble in distilled water, pH 7.4 phosphate buffer, and acetonitrile; slightly soluble in ethanol; and freely soluble in methanol. In a post-hoc analysis, Lipitor 80 mg reduced the incidence of ischemic stroke (218/2365, 9.2% vs. In this limited controlled study, w w w lipitor com was no significant effect on growth or sexual maturation in boys or on menstrual cycle length in girls . Lipitor significantly reduced the rate of major cardiovascular events (primary w w w lipitor com events) (83 events in the Lipitor group vs. Discuss the use of grapefruit products w w w lipitor com your doctor. USE IN SPECIFIC POPULATIONS 8.1 Pregnancy Pregnancy Category X Lipitor is contraindicated in women who are or may become pregnant. Who Should Not Take Lipitor? Do not take Lipitor if you: are pregnant or think you may be pregnant, or w w w lipitor com planning to become pregnant. The concomitant use of higher doses of atorvastatin with certain drugs such as cyclosporine and strong CYP3A4 inhibitors (e.g., clarithromycin, itraconazole, and HIV protease inhibitors) increases the risk of myopathy/rhabdomyolysis. 2.3 Homozygous Familial Hypercholesterolemia The dosage of Lipitor in patients w w w lipitor com homozygous FH is 10 to 80 mg daily. Most effects tended to be mild and transient. Mean plasma elimination w w w lipitor com of Lipitor in humans is approximately 14 hours, but the half-life of inhibitory activity for HMG-CoA reductase is 20 to 30 hours due to the contribution of active metabolites. ‡ Significantly different from pravastatin, ANCOVA, p ≤0.05 § Significantly different from simvastatin, ANCOVA, p ≤0.05 The impact on clinical outcomes of the differences in lipid-altering effects between treatments shown in Table 7 is not known. See also: Lipitor side effects w w w lipitor com more detail) What other drugs will affect Lipitor? Before taking Lipitor, tell your doctor about all other medicines you are using, especially: birth control pills; cimetidine (Tagamet); digoxin (Lanoxin); efavirenz (Sustiva, Atripla); rifampin (Rifater, Rifadin, Rifamate); spironolactone (Aldactone, Aldactazide); or any w w w lipitor com "statin" medication such as amlodipine and atorvastatin (Caduet), fluvastatin w w w lipitor com lovastatin (Altoprev, Mevacor), pravastatin (Pravachol), rosuvastatin (Crestor), o simvastatin (Zocor, Simcor, Vytorin). It's important to avoid taking the two drugs at the same time of day. Your doctor may want to do a blood test to check for signs of muscle damage.
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