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Sporadic reports have been received of congenital abnormalities occurring in infants born to women who have received omeprazole during pregnancy. Remember, keep this and all other medicines out of the reach of children, never share your medicines nexium sales 2008 others, and use this medication only for the indication prescribed. Esomeprazole nexium sales 2008 not expected to harm an unborn baby. Antisecretory Activity The effect of intravenous esomeprazole on intragastric pH was determined in two separate studies. If symptoms persist, your doctor may prescribe an additional 4 weeks of therapy. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Copyright 1996-2006 Cerner Multum, Inc. Take Nexium Delayed-Release Capsules by mouth on an empty stomach at least 1 hour before eating. Nexium Delayed-Release Capsules may interfere with certain lab tests. However, in patients with severe hepatic insufficiency (Child Pugh Class C) a dose of 20 mg once daily should not be exceeded (See DOSAGE AND ADMINISTRATION). nexium sales 2008 Store at 25°C (77°F); excursions permitted to 15°-30°C (59°-86°F). You may report side effects to FDA at 1-800-FDA-1088. Patients treated with proton pump inhibitors and warfarin concomitantly may need to be monitored for increases in INR and prothrombin time. The intravenous line should always be flushed with either 0.9% Sodium Chloride Injection, USP, Lactated Ringer’s Injection, USP or 5% Dextrose Injection, USP both prior to and after administration of Nexium I.V. Intravenous treatment with esomeprazole 20 and 40 mg administered as an injection or as an infusion was found to have a safety profile similar to that of oral administration of esomeprazole 20 and 40 mg. Reports have been received of overdosage with oral omeprazole in humans. Do not breast-feed while using Nexium I.V.. Possible side effects of Nexium I.V.: All medicines may cause side effects, but many people have no, or minor, side effects. Nexium Delayed-Release Capsules All medicines may cause side effects, but many people have no, or minor, side effects. The remaining amount nexium sales 2008 dependent on CYP3A4 which forms the sulphone metabolite.

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for Injection on Intragastric pH on Day 5* Esomeprazole 20 mg Esomeprazole 40 mg (n=22) (n=38) * Gastric pH was measured over a 24-hour period % Time Gastric 49.5 66.2 PH>4 (95% CI) 41.9-57.2 62.4-70.0 Serum Gastrin Effects In oral studies, nexium sales 2008 effect of Nexium on serum gastrin concentrations was evaluated in approximately 2,700 patients in clinical trials up to 8 weeks and in over 1,300 patients for up to 6-12 months. FDA pregnancy category B. In one of these studies, female rats were treated with 13.8 mg omeprazole/kg/day (about nexium sales 2008 times the human dose on a body surface area nexium sales 2008 for 1 year, then followed for an additional year without the drug. Over a 10 week period, she experienced a decline in sexual function until she could no longer respond sexually. In vitro and in vivo studies have shown that esomeprazole is not likely to inhibit CYPs 1A2, 2A6, 2C9, 2D6, 2E1 and 3A4. is found in breast milk. This information is a nexium sales 2008 only. Special information if you are pregnant or breastfeeding The effects of Nexium during pregnancy have not been adequately studied.